Protein Modification Reagents
Medchemexpress LLC Pomalidomide-PEG4-C-COOH | 2097938-44-6 | 99.2% | 507.49 | 5 MG
Pomalidomide-PEG4-C-COOH (Cereblon Ligand -Linker Conjugate 1) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Pomalidomide based cereblon ligand
- Uses 4-unit PEG linker
- Used in PROTAC technology
eMolecules 1870899-46-9 | DBCO-NHCO-PEG5-acid | Broadpharm | MFCD28334546 | 596.677 | C32H40N2O9 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCC(=O)NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 500mg | 268505101
DBCO-NHCO-PEG5-acid | Broadpharm | 1870899-46-9 | MFCD28334546 | 596.677 | C32H40N2O9 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCC(=O)NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 500mg | 268505101
eMolecules Methyltetrazine-PEG23-NH-Boc | Broadpharm |1344.595 | C62H113N5O26 | 0.000 | Cc1nnc(nn1)-c1ccc(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OC(C)(C)C)cc1 | 5mg | 411413934
Methyltetrazine-PEG23-NH-Boc | Broadpharm |1344.595 | C62H113N5O26 | 0.000 | Cc1nnc(nn1)-c1ccc(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OC(C)(C)C)cc1 | 5mg | 411413934
Broadpharm TCO-PEG12-NHS ester, 2185016-39-9, MFCD30536161, 10mg
Formula: C40H70N2O18, Purity: 98%, MW: 867.0, TCO-PEG12-NHS Ester is a PEG derivative containing a TCO moiety and a NHS ester. The hydrophilic PEG spacer increases water-solubility and a decreases steric hindrance during ligation. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety.
Medchemexpress LLC Bromoacetamido-PEG5-DOTA | 2353410-19-0 | 98.0% | C30H55BrN6O13 | 1 MG
Bromoacetamido-PEG5-DOTA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It is for research use only and not sold to patients.
- Molecular weight: 787.69
- Formula: C30H55BrN6O13
- Cas no.: 2353410-19-0
- Appearance: Oil
- Color: White to off-white
- Purity: 98.02%
Medchemexpress LLC Biotin-PEG4-NHS ester | 459426-22-3 | MFCD08458915 | 99.6% | C25H40N4O10S | 500 MG
Biotin-PEG4-NHS ester is a biotin-labeled, PEG-based PROTAC linker. It is designed for use in the synthesis of PROTACs, compounds that exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is for research use only.
- Designed for use in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Consists of two different ligands connected by a linker
- One ligand binds to an E3 ubiquitin ligase
- The other ligand binds to the target protein
Medchemexpress LLC DSPE-PEG-DBCO sodium | 2052955-83-4 | 95.0% | 5000 (average) | 1 MG
DSPE-PEG-DBCO sodium (MW 5000) is a PEGylated phospholipid that combines a DSPE lipid anchor with a dibenzocyclooctyne (DBCO) reactive handle, designed for incorporation into lipid formulations and for strain-promoted alkyne-azide cycloaddition (SPAAC) bioconjugation in drug delivery research.
- Pegylated lipid with DBCO functionality for copper-free click chemistry.
- Sodium salt form supplied as a white to yellow solid.
- Average molecular weight approximately 5000 daltons.
- Purity approximately 95% by supplier analysis.
- Enables liposome and nanoparticle surface functionalization.
- Store at -20°C and protect from light; follow solvent storage guidance for long-term stability.
Medchemexpress LLC PC-Biotin-PEG4-NHS carbonate | 2055198-03-1 | 810.87 | 50 MG
PC-Biotin-PEG4-NHS carbonate is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase and the other is for the target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Azido-PEG3-NHS ester | 1245718-89-1 | MFCD23726613 | 99.9% | 344.32 g/mol | C13H20N4O7 | 5 G
N3-PEG3-C2-NHS ester (Azido-PEG3-NHS ester) is a non-cleavable, azide-terminated three-unit polyethylene glycol linker bearing an N-hydroxysuccinimide (NHS) ester reactive group used for conjugation to primary amines and for click chemistry applications.
- Non-cleavable azide-terminated PEG3 linker for bioconjugation.
- NHS ester selectively reacts with primary amines for efficient coupling.
- Compatible with azide-alkyne cycloaddition (click chemistry) for downstream functionalization.
- High purity suitable for research applications.
- Stable under recommended storage conditions: pure form at -20°C; in solvent at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Methyltetrazine-PEG5-alkyne | 1802907-97-6 | 98.0% | C20H26N4O5 | 100 MG
Methyltetrazine-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs contain two different ligands connected by a linker
- One ligand for an E3 ubiquitin ligase
- Other ligand for the target protein
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
![Research Products International Corp PEG 8000 [Polyethylene Glycol 8000], 5 Kilograms](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00006095-P48080-5000.0.JPG-250.jpg)
Research Products International Corp PEG 8000 [Polyethylene Glycol 8000], 5 Kilograms
Ultrapure white crystals for molecular biology applications such as precipitation of DNA, nucleic acids, hybridization and fusion of mammalian cells.Melting Point: 55°-60°C
Medchemexpress LLC Bis-PEG4-PFP ester | 1314378-12-5 | 97.0% | 500 MG
Bis-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- PROTACs consist of two different ligands connected by a linker.
- One ligand targets an E3 ubiquitin ligase.
- The other ligand targets the protein of interest.
- PROTACs utilize the intracellular ubiquitin-proteasome system.
- Selectively degrade target proteins.
Medchemexpress LLC N3-PEG4-C2-NHS ester | 944251-24-5 | 98.9% | 5 G
N3-PEG4-C2-NHS ester is a non-cleavable 4-unit PEG linker utilized in the synthesis of antibody-drug conjugates (ADCs). It functions as a click chemistry reagent, containing an Azide group. This allows it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules that contain Alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- Non-cleavable 4-unit PEG linker
- Used in synthesis of antibody-drug conjugates (ADCs)
- Functions as a click chemistry reagent
- Contains an Azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions